phenobarbital will lessen the extent or influence of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Solid or reasonable CYP3A4 inducers may boost level of diazepam elimination; consequently, efficacy of diazepam may very well be lessened.Utilization in Pregnancy. Barbiturates might cause fetal problem